Restoration work was conducted on the painted frescos belonging to the monument known as the Serapeum at Hadrian’s Villa. Between 1976 and 1978, ca. 250 sq. m. of frescoes decorated with squares filled with vegetal motif were removed from the vault in order to save them from the damage caused by the infiltration of water. Those interventions, carried out with methods now surpassed, have themselves caused damage such as the fragmentation of the plaster, the deterioration of the pictorial layer, and the formation of salts on the painted surface. The current operations have focused on a sample of fresco approximately 50 square meters in size, and have removed as result the layers of the preceding restoration. This was followed by new interventions of consolidation, cleaning, elimination of the integrations in plaster, sealing of the supports and final repositioning. Investigations of fluorescence and thermography have provided knowledge of the composition of the layer as well as the state of the vault of the corridor of the Serapeum, on which the frescoed panels will be replaced.