Structural remains and ceramics of Roman and medieval date came to light in Brindisi’s historic centre during restructuring work on a ground floor apartment in Via Lauro 32, to the rear of the medieval church of S. Giovanni al Sepolcro. The Archaeological Superintendency carried out a rescue excavation, opening three trenches across the room in order to check the nature of the archaeological structures. The earliest remains were part of a road and a Greek-style _opus_ _quadratum_ wall built of large tufa blocks, part of a Roman _insula_. The wall delimited the south-east side of a space in front of the _fauces_ of a _domus_ that extended beyond the north wall of the modern building, continuing below the medieval church of S. Giovanni al Sepolcro. To the south, the wall faced onto a _cardo_ that was part of the ancient street network. Part of the paved road surface was uncovered, about one third of its original width. It was bordered by a kerb of tufa blocks with an _opus_ _signinum_ surface. An occupation phase subsequent to the construction of the _insula_ was documented in trenches 1 and 3 by a sequence of levelling layers, which raised the level of the road surface. Trench 3 revealed evidence of medieval occupation in the form of a wall built on top of the layers obliterating the _domus_ and medieval pottery was found in trench 2, whose fill produced mainly majolica and glazed wares.