In 2006, the excavations inside Palazzo Melatino uncovered the well-preserved structures and floors of a _domus_. It falls within an urban area where numerous archaeological discoveries have been made, such as the _domus_ del Leone in Via di Porta Carrese, Vico delle Ninfe, Via dei Mille, and the _domus_ di Madonna delle Grazie. The artisans who decorated the rooms of the _domus_ del Melatino were inspired by known models echoing Pompeian mosaics and the rich marble floors of Imperial Rome. The large peristyle of the phase I _domus_ has various parallels in 1st century B.C. Pompeian rooms, as the frescoed wall that closes the room, with painting imitating encrustations of polychrome marble arranged a telaio, is similar to the Pompeian II Style. The large central room of the phase II _domus_, which was probable a reception room, had an _opus_ _sectile_ floor echoing those in the wealthy Roman _domus_, in particular those in Hadrian’s villa, as beautiful the phase III _opus_ _sectile_ floor seemed to be inspired by the recently discovered floor below Palazzo Valentini in Rome. The careful choice of style and the richness of the materials attest the economic and political importance of the owners of the _domus_ within the dominant class in the city of _Interamnia_ throughout the imperial period until late antiquity.